From HealthDay:

“It is not possible to know the detailed smoking history of every subject, and there’s a myriad of subtle differences in consumption. There is little doubt that there is a difference in risk between one cigarette per day and 20, but it is not possible to measure all gradations in between,” said Brad Rodu, a professor of medicine at the University of Louisville. “The other problem is reliability. Smokers who report fewer cigarettes might be underreporting, or they might be compensating by smoking more intensely.”

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